The time it takes Amgen to conduct clinical trials and obtain administrative approval for the commercialization of the product has been different in the past and Amgen expects similar variability in the future. Amgen develops product candidates internally and through licensing, partnerships, joint ventures and acquisitions. Product applicants who arise from relationships or acquisitions may be subject to disputes between the parties or may not be as effective or less secure as Amgen believed at the time of entering into such a relationship. In addition, amgen or other safety, side effect or manufacturing issues may identify Amgen products after they have been put on the market. Amgen`s business may be affected by administrative investigations, litigation and product liability claims.